教師簡介

  • 專任副教授
  • 可文亞
  • Wen-Ya Ko
  • 02-2826-7979／lab: 66082 or 66069
  • wenko@nycu.edu.tw
  • 圖書資訊暨研究大樓6樓R629
  • 專業領域
  • 族群遺傳學、族群基因體學、演化學
  • 研究方向

  • Research in our laboratory mainly focuses on identifying evolutionary forces that underlie patterns of genetic variation and the roles of adaptive/deleterious variants in disease susceptibility in diverse ethnic groups of humans. We are broadly interested in studying a variety of topics including identifying recent evolutionary adaptation in diverse human ethnic groups, admixed ancestry characterization of human genomes, genome evolution, and conservation genetics. Current research projects include:

    • Admixed ancestry characterization of human genomes
    • Identifying genetic signatures of recent adaptation in humans
    • Phenome-wise association studies on evolutionary deleterious variants in humans
    • Polygenic adaption and risk-score prediction of metabolic and cardiovascular traits in human populations
    • Conservation genetics of endangered Taiwanese fruit bats (Pteropus dasymallus formosus)

  • 教授科目
  • 遺傳學概論
    分子族群遺傳學與基因體資料分析
    生命科學技術
    生物統計學
    分子演化與醫學
    生命科學教學
  • 獲獎
  • 2013-2015
    Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship for Foreign Researchers
  • Nov. 2-6 2010
    Trainee Research Semifinalist Award for the 60th annual meeting of the American Society of Human Genetics (ASHG)
  • Jul. 4-8 2010
    Postdoctoral Research Travel Award for the Society of Molecular Biology and Evolution (SMBE)
  • Mar. 22-25 2010
    Burroughs Wellcome Travel Scholarship for Ecology and Evolution of Infectious Diseases (EEID) Meeting
  • 2006
    Biology Graduate Student Research Excellence Awards
  • 經歷
  • Aug, 2021-present
    國立陽明交通大學
    生命科學系暨基因體科學研究所
    副教授
  • Aug, 2015-July, 2021
    國立陽明大學
    生命科學系暨基因體科學研究所
    助理教授
  • Jul 2019 – Aug 2019 & Jul 2022 – Aug 2022
    SOKENDAI
    Department of Evolutionary studies of biosystems, School of advanced sciences, The Graduate University for Advanced Studies
    訪問學者
  • Dec, 2012 – Sep, 2013
    Campus Agrário de Vairão, University of Porto
    Research Center of Biodiversity and Genetic Resources (CIBIO)
    助研究員
  • 學歷
  • 2007
    美國賓州州立大學
    生物學　博士 (分子演化學專長)

代表著作

    期刊發表

  • Yun-Hua Lo, Hsueh-Cheng Cheng, Han-Yu Wang, Chia-Wei Peng, Chun-Yo Chen et al., Wen-Ya Ko. 2021. Detecting genetic ancestry and adaptation in the Taiwanese Han people. Molecular Biology and Evolution. Sep 27;38(10): 4149-4165 (Published online: 10 November 2020; IF= 16.240)(corresponding author).
  • K-P Lin, S-M Chaw, Y-H Lo, T Kinjo, C-Y Tung, H-C Cheng, Q Liu, Y Satta, M Izawa, S-F Chen, and Wen-Ya Ko. 2020. Genetic differentiation and demographic trajectory of the insular Formosan and Orii’s flying foxes. 2020. Journal of Heredity (accepted; IF: 2.809, ranking: Q1 in Biotechnology) (corresponding author).
  • S.-F. Chen, C.-H. Juan, S. J. Rossiter, T. Kinjo, D. Fukui, K. Kawai, S. M. Tsang, M. J. Veluz, H. Sakurai, H.-C. Lin, N.-H. Jang-Liaw, K. Osawa, W.-Y. Ko, and M. Izawa. Population Genetic Structure of the Insular Ryukyu Flying Fox Pteropus dasymallus. 2021. Biotropica 53(2):548-559. (impact factor = 2.09; ranking: Q1 in Ecology, Evolution, Behavior and Systematics) (co-corresponding author)
  • Yun-Hua Lo, Hsueh-Cheng Cheng, Han-Yu Wang, Chia-Wei Peng, Chun-Yo Chen et al., Wen-Ya Ko. 2020. Detecting genetic ancestry and adaptation in the Taiwanese Han people. Molecular Biology and Evolution. (ahead of print; IF: 16.24) (corresponding author)
  • Laura B. Scheinfeldt, Sameer Soi, Charla Lambert, Wen-Ya Ko, et al. 2019. Genomic evidence for shared common ancestry of East African hunting-gathering populations and insights into local adaptation. 2019. Proc Natl Acad Sci U S A, 116 (10) 4166-4175. (IF:9.4).
  • Higasa, K., Miyake, N., Yoshimura, J., Okamura, K., Niihori, T., Saitsu, H., et al., 2016. Human genetic variation database, a reference database of genetic variations in the Japanese population. Journal of Human Genetics.(IF=2.9)
  • Ranciaro A., Campbell M. C., Hirbo J. B., Ko, W.-Y., et al., 2014. Genetic Origins of Lactase Persistence and the Spread of Pastoralism in Africa. Am J Hum Genet 94: 496-510.(IF=10.5)
  • Ko, W.-Y., P. Rajan, F. Gomez, et al., 2013 Darwinian selection acting on different human APOL1 variants among diverse African populations. Am J Hum Genet 93: 90-102.(IF=10.5)
  • Gomez F., Tomas G., Ko, W.-Y. et al. Patterns of Nucleotide and Haplotype Diversity at ICAM-1 Across Global Human Populations with Varying Levels of Malaria Exposure. Human Genetics 132: 987-999. (IF=5.7)
  • Ko, W.-Y., K. Kaercher, E. Giombini et al., 2011 Effects of gene conversion and natural selection on the evolution of human glycophorins coding for MNS polymorphism in malaria endemic African populations. Am J Hum Genet 88: 741-754 (selected as a featured article).(IF=10.5)
  • Iida, K., D. L. Cox-Foster, X. Yang, W.-Y. Ko, D. R. Cavener, 2007 Expansion and evolution of insect GMC oxidoreductases. BMC Evolutionary Biology 7:75.
  • Ko, W.-Y., S. Piao, and H. Akashi., 2006 Strong regional heterogeneity in base composition evolution on the Drosophila X chromosome. Genetics 174:349-362.
  • Akashi, H., W.-Y. Ko, S. Piao, A. John, P. Goel, C. F. Lin, and A. Vitins, 2006 Molecular evolution in the Drosophila melanogaster species subgroup: Frequent parameter fluctuations on the time-scale of molecular divergence. Genetics 172: 1711-1726.
  • Ko, W.-Y., R. David, and H. Akashi, 2003 Molecular phylogeny of the Drosophila melanogaster species subgroup. J. Mol. Evol. 57: 562-573.
  • Tishkoff, S. A., M. Campbell, and J. Hirbo, J. Jarvis, W.-Y. Ko et al., 2010 Genomic variation and adaptation in Africa: Implications for human evolutionary history and disease. Genome Biology 11 (Suppl 1): 120.

    專書發表

  • Ko, W.-Y., Gomez, F., and S. A. Tishkoff., 2012 Evolution of human erythrocyte-specific genes involved in malaria susceptibility, a chapter in "Evolution In The Fast Lane: Rapidly Evolving Genes and Genetic Systems. Singh R. S., Xu J. and Kulathinal R. J. Ed. Oxford University Press, Oxford.
  • Gomez, F., W.-Y. Ko, A. Davis, and S. A. Tishkoff. Impact of Natural Selection due to Malarial Disease on Human Genetic Variation. In J.F. Brinkworth and K. Pechenkina (eds) "Primates, Pathogens and Evolution. Developments in Primatology: Progress and Prospects" 38:117-160 Springer publishing, New York.

    研討會發表 (in 5 years)

  • Yun-Hua Lo, Han-Yu, Wang, Chia-Wei Peng, Chun-Yu Chen, Hsueh-Chien Cheng, Shu-Miaw Chaw, Marie Lin and Wen-Ya Ko*. Distinct patterns of genetic ancestry and adaptation in the islanders of Taiwan. 2019 annual meeting of the American Society of Human Genetics (ASHG), Houston TX, Oct 15 - 19, 2019 (*Corresponding author)
    *Poster presentation
  • Wen-Ya Ko*, Koichiro Higasa, Han-Yu Wang, Yun-Hwa Lo, Maiko Narahara, Kaori Iida, Fumihiko Matsuda, and Ryo Yamada. Genetic origins and admixed ancestry characterization of Japanese people. International Symposium on Integrated Anthropology From Genetics to Ecology, Biodiversity – conservation of organisms, Cultures, and Ethnicities. SOKENDAI, Hayama, Japan. Feb.1, 2019 (*Invited talk)
  • Wen-Ya Ko*, Koichiro Higasa, Han-Yu Wang, Yun-Hwa Lo, Maiko Narahara, Kaori Iida, Fumihiko Matsuda, and Ryo Yamada. Genetic origins and admixed ancestry characterization of Japanese people. The 16th Korea-Japan-China Bioinformatics Symposium Aug 29-31 2018 (*Invited talk)
  • Symposium on Evolutionary Genetics and Omics. National Institute of Genetics, Mishima, Japan, July 13-14 2018
    *Oral presentation (x 2)
    (1) Wen-Ya Ko*, Koichiro Higasa, Han-Yu Wang, Yun-Hwa Lo, Maiko Narahara, Kaori Iida, Fumihiko Matsuda, and Ryo Yamada. Genetic origins and admixed ancestry characterization of Japanese people. (*1st author and Corresponding author)
    (2) Yun-Hua Lo, Han-Yu, Wang, Chia-Wei Peng, Chun-Yu Chen, Hsueh-Chien Cheng, Shu-Miaw Chaw, Marie Lin and Wen-Ya Ko*. Genetic adaptation and ancestry inference of Taiwanese people. (*Corresponding author)
  • The annual meeting of the Society for Molecular Biology and Evolution (SMBE), Pacifico Yokohama, Japan, July 8- 12, 2018
    *Poster presentation (x 3)
    (1) Wen-Ya Ko*, Koichiro Higasa, Han-Yu Wang, Yun-Hwa Lo, Maiko Narahara, Kaori Iida, Fumihiko Matsuda, and Ryo Yamada. Genetic origins and admixed ancestry characterization of Japanese people. (*1st author and Corresponding author)
    (2) Yun-Hua Lo, Han-Yu, Wang, Chia-Wei Peng, Chun-Yu Chen, Hsueh-Chien Cheng, Shu-Miaw Chaw, Marie Lin and Wen-Ya Ko*. Genetic adaptation and ancestry inference of Taiwanese people. (*Corresponding author)
    (3) Kung-Ping Lin, Yun-Hwa Lo, Shiang-Fan Chen, Masako Izawa, Wen-Ya Ko*. Uncovering the demographic history of the endangered Formosan fruit bats (Pteropus dasymallus formosus) in Taiwan. (*Corresponding author)
  • Ko W.-Y., K. Higasa, M. Narahara, F. Matsuda, and R. Yamada,. Genetic origins and admixed ancestry characterization of Japanese people. The 65th annual meeting of the American Society of Human Genetics (ASHG), Baltimore MD, Nov 6 - 10, 2015 *Poster presentation

    邀請演講 (in 5 years)

  • Wen-Ya Ko*, Koichiro Higasa, Han-Yu Wang, Yun-Hwa Lo, Maiko Narahara, Kaori Iida, Fumihiko Matsuda, and Ryo Yamada. Genetic origins and admixed ancestry characterization of Japanese people. International Symposium on Integrated Anthropology From Genetics to Ecology, Biodiversity – conservation of organisms, Cultures, and Ethnicities. SOKENDAI, Hayama, Japan. Feb.1, 2019 (*Invited talk)
  • Wen-Ya Ko*, Koichiro Higasa, Han-Yu Wang, Yun-Hwa Lo, Maiko Narahara, Kaori Iida, Fumihiko Matsuda, and Ryo Yamada. Genetic origins and admixed ancestry characterization of Japanese people. The 16th Korea-Japan-China Bioinformatics Symposium Aug 29-31 2018 (*Invited talk)
  • Symposium on Evolutionary Genetics and Omics. National Institute of Genetics, Mishima, Japan, July 13-14 2018
    *Oral presentation (x 2)
    (4) Wen-Ya Ko*, Koichiro Higasa, Han-Yu Wang, Yun-Hwa Lo, Maiko Narahara, Kaori Iida, Fumihiko Matsuda, and Ryo Yamada. Genetic origins and admixed ancestry characterization of Japanese people. (*1st author and Corresponding author)
    (5) Yun-Hua Lo, Han-Yu, Wang, Chia-Wei Peng, Chun-Yu Chen, Hsueh-Chien Cheng, Shu-Miaw Chaw, Marie Lin and Wen-Ya Ko*. Genetic adaptation and ancestry inference of Taiwanese people. (*Corresponding author)

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