其他師資
專任師資
兼任師資
合聘師資
退休師資
教師簡介
- 專任教授
- 俞震亞
- Jenn-Yah Yu
- 02-2826-7921／lab: ext. 66242
- jyyu@nycu.edu.tw
- 圖書資訊暨研究大樓7樓R725
- 專業領域
- 發育生物學、細胞生物學、神經發育
- 研究方向
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在發育的胚胎或是由幹細胞維持的成體器官中，細胞的分裂與分化過程都需要被很精確地調控；如果調控發生錯誤，會造成組織異常萎縮或癌 症。因此我們需要了解調控細胞分裂與分化的分子機制。
我們實驗室的主要利用果蠅的卵巢為生物模式。一隻母果蠅有一對卵巢，可以終其一生不斷地產卵。這些卵來自卵巢中的生殖幹細胞與濾泡幹細 胞；這兩種幹細胞都能進行自我更新與細胞分裂，產生新的細胞；這些細胞會進行分裂、分化、遷移、型態改變與細胞凋亡。配合果蠅的遺傳工 具，我們可以用卵巢為模式，深入探討不同的基因與訊息傳遞路徑如何影響上述細胞的各種行為與功能。
- 教授科目
- 細胞生物學
遺傳學概論
幹細胞與再生
- 經歷
- 2023-present
國立陽明交通大學
生命科學系暨基因體科學研究所
教授 - 2014-2023
國立陽明交通大學
生命科學系暨基因體科學研究所
副教授 - 2008-2014
國立陽明大學
生命科學系暨基因體科學研究所
助理教授 - 2006-2008
美國華盛頓大學生物化學
博士後研究 - 學歷
- 2008
美國密西根大學
神經科學 博士 - 1995
國立臺灣大學
動物學研究所 碩士 - 1993
國立臺灣大學
動物學系 學士
代表著作
- Chia-Lin Wu, Jhih-Wen Hsu, Ya-Chi Chan, Jenn-Yah Yu, Yi-Liang Tsai, Der-Cherng Tarng. Depleting Yes-Associated Protein in Gli1-Expressing Cells Attenuates Peritoneal Dialysis-Induced Peritoneal Fibrosis. Journal of Cellular and Molecular Medicine 2025, 29(6):e70516.
- Yu-Sheng Hung, Wei-Mi Lin, Yu-Chiuan Wang, Wei-Chih Kuo, Yu-Yang Chen, Ming-Ji Fann, *, Yu-Hui Wong*. Protogenin facilitates trunk-to-tail HOX code transition via modulating GDF11/SMAD2 signaling in mammalian embryos. Communications Biology 2024, 1669. (SCI, 13/109, BIOLOGY). NSTC 112-2311-B-A49-003. 本人為通訊作者.
- Ming-Yang Li, Xiu-Li Yang, Chia-Chi Chung, Yun-Ju Lai, Jui-Cheng Tsai, Ya-Lin Kuo, *, Tsu-Wei Wang*. TRIP6 promotes neural stem cell maintenance through YAP-mediated Sonic Hedgehog activation. FASEB Journal 2024, 38(5):e23501. (SCI, 77/205, CELL BIOLOGY). 本人為通訊作者.
- Tsai-Chu Yeh#, Hui-Chen Cheng#, Hsing-Yuan Li, Sheng Chu Chi, Hsin-Yu Yang, Jenn-Yah Yu, Dau-Ming Niu*, An-Guor Wang*. Ophthalmic characteristics and retinal vasculature changes in Williams syndrome, and its association with systemic diseases. Eye 2023, 37(11):2265-2271. (SCI, 23/95, OPHTHALMOLOGY).
- Hui-Chen Cheng, Sheng-Chu Chi, Chiao-Ying Liang, Jenn-Yah Yu, An-Guor Wang. Candidate Modifier Genes for the Penetrance of Leber's Hereditary Optic Neuropathy. International Journal of Molecular Sciences 2022, 23(19):11891.
- Yi-Ching Su, Tzu-Heng Hung, Tzu-Fang Wang, Ying-Hsuan Lee, Tsu-Wei Wang*, *. YAP maintains the production of intermediate progenitor cells and upper-layer projection neurons in the mouse cerebral cortex. Developmental Dynamics 2022, 251(5):846-863. (SCI, 2/21, Anatomy & Morphology). MOST 106-2311-B-010-003. 本人為通訊作者.
- Huang YC, Chen KH, Chen YY, Tsao LH, Yeh TH, Chen YC, Wu PY, Wang TW, *, bPS-Integrin acts downstream of Innexin 2 in modulating stretched cell morphogenesis in the Drosophila ovary. G3 Genes|Genomes|Genetics 2021.
- Li MY, Chang CT, Han YT, Liao CP, *, Wang TW*. Ginkgolide B promotes neuronal differentiation through the Wnt/β-catenin pathway in neural stem cells of the postnatal mammalian subventricular zone. Sci Rep. 2018 Oct 8;8(1):14947.
- Hsu TH, Yang CY, Yeh TH, Huang YC, Wang TW, *. The Hippo pathway acts downstream of the Hedgehog signaling to regulate follicle stem cell maintenance in the Drosophila ovary. Sci Rep. 2017 Jun 30;7(1):4480.
- Liu YH, Tsai JW, Chen JL, Yang WS, Chang PC, Cheng PL, Turner DL, Yanagawa Y, Wang TW*, *. Ascl1 promotes tangential migration and confines migratory routes by induction of Ephb2 in the telencephalon. Sci Rep. 2017 Mar 9;7:42895.
- Yeh TH, Huang SY, Lan WY, Liaw GJ*, *. Modulation of cell morphogenesis by tousled-like kinase in the Drosophila follicle cell. Dev Dyn. 2015 Jul;244(7):852-65.
- Lin TH, Yeh TH, Wang TW, *. The Hippo pathway controls border cell migration through distinct mechanisms in outer border cells and polar cells of the Drosophila ovary. Genetics. 2014 Nov;198(3):1087-99.
- Chiu YC, Li MY, Liu YH, Ding JY, *, Wang TW*. Foxp2 regulates neuronal differentiation and neuronal subtype specification. Dev Neurobiol. 2014 Jul;74(7):723-38.
- Liu YH, Lai WS, Tsay HJ*, Wang TW*, *. Effects of maternal immune activation on adult neurogenesis in the subventricular zone-olfactory bulb pathway and olfactory discrimination. Schizophr Res. 2013 Dec;151(1-3):1-11.
- Wu JH, Han YT, , Wang TW. Pheromones from males of different familiarity exert divergent effects on adult neurogenesis in the female accessory olfactory bulb. Dev Neurobiol. 2013 Aug;73(8):632-45.
- Lin YT, Ding JY, Li MY, Yeh TS, Wang TW*, *. YAP regulates neuronal differentiation through Sonic hedgehog signaling pathway. Exp Cell Res. 2012 Sep 10;318(15):1877-88.
- Chen HJ, Wang CM, Wang TW, Liaw GJ, Hsu TH, Lin TH, *. The Hippo pathway controls polar cell fate through Notch signaling during Drosophila oogenesis. Dev Biol. 2011 Sep 15;357(2):370-9.
期刊論文