教師簡介

  • 專任副教授
  • 翁芬華
  • Fen-Hwa Wong
  • 02-2826-7240
  • fhwa@nycu.edu.tw
  • 傳統醫學大樓甲棟1樓R109
  • 專業領域
  • 小鼠上顎發育、腫瘤生物學、訊息傳遞
  • 研究方向
    • Esophageal carcinoma is one of the leading causes of death in Taiwan. The combination of chemotherapeutic agents with radiotherapy enhance the therapeutic efficacy by ablation the survival mechanism, i.e. cause massive apoptosis, of esophageal carcinoma. However, survival signals, i.e. production of IGF-1 and EGF in esophageal carcinoma cells, cause the cancer cells to escape from apoptosis. We are interested in investigating which signaling pathway is responsible for the IGF-1R and EGFR survival signal in esophageal carcinoma, by using various chemical signaling blockers, dominant negative mutants, and shRNA to narrow down the IGF-1 and EGF-mediated survival signal in esophageal carcinoma. The identified pathway will be used as a template to address which signaling components are important for IGF-1R and EGFR induced survival signals in esophageal carcinoma. Recently, we focus on two IGF-1 regulated anti-apoptosis molecules, aurora A, survivin and XIAP. The roles of the two genes in IGF-1R mediated survival pathway are under investigation.
    • Cleft lip/palate is one of the most common congenital diseases in Taiwan, and van der Woude syndrome is the most important syndrome in cleft lip/palate. The mutation of IRF6 gene causes the van der Woude syndrome, thus IRF6 is a good candidate gene for studying the mechanisms of formation of cleft lip/palate. We try to understand the molecular mechanisms of IRF6 on the palate shelves fusion by organ culture and knockout mouse. We try to identify the target genes regulated by IRF6 in palate epithelial cells during palate formation. Our goal is to understand the molecular mechanism of mutated IRF6 on the formation of cleft palate during the palate shelves fusion and therefore lay a good foundation for possible therapeutic intervention and prevention of cleft palate in the high-risk group.
  • 教授科目
  • 生物學及實驗
    普通生物學及實驗
    癌症生物學
    論文閱讀與分析方法（一）、（二）
    生命科學教學
  • 經歷

  • 2004-present
    國立陽明交通大學
    生命科學系暨基因體科學研究所
    副教授
  • 1996-2004
    國立陽明大學公共衛生研究所
    副教授
  • 1993-1996
    美國華盛頓大學
    博士後研究
  • 1992-1993
    臺北榮總教研部
    博士後研究
  • 學歷
  • 1992
    國立陽明大學
    微生物及免疫學研究所　博士
  • 1981 國立臺灣大學
    植物病蟲害學系病理組　碩士
  • 1979
    國立臺灣大學
    植物病蟲害學系病理組　學士

代表著作

  • 1. Ke CY, Xiao WL, Chen CM, Lo LJ*, Wong FH*. IRF6 is the mediator of TGFβ3 during regulation of the epithelial mesenchymal transition and palatal fusion. Sci. Rep. 5, 12791; doi: 10.1038/srep12791, 2015.
  • 2. David-Paloyo FP, Yang X, Lin JL, Wong FH*, Wu-Chou YH, Lo LJ. Lower Lip Pits: Van der Woude or Kabuki Syndrome? Cleft Palate Craniofac J. 51(6):729-34, doi: 10.1597/12-258, 2014.
  • Juan HC, Tsai HT, Chang PH, Huang F CY, Hu C, Wong FH. Insulin-like growth factor 1 mediates 5-fluorouracil chemoresistance in esophageal carcinoma cells through increasing survivin stability. Apoptosis: DOI: 10.1007/s10495-010-0555-z, 2010.
  • Wong FH, Huang F C-Y, Su LJ, Wu YC, Lin YS, Hsia JY, Tsai HT, Lee SA, Lin CH, Liang SC, Lai JM, Yen CC. Combination of microarray profiling and protein-protein interaction databases delineates the minimal discriminators as a metastasis network for esophageal squamous cell carcinoma. Int J Oncology 34: 117-128, 2009.
  • Chou WC, Wang HC, Wong FH, Ding SL, Wu PE, Shieh SY, Shen CY. Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. EMBO 27: 3140–3150, 2008
  • Chau GY, Lee A FY, Tsay SH, Ke YR, Kao HL, Wong FH, Tsou AP, Chau YP. Clinicopathological significance of survivin expression in patients with hepatocellular carcinoma. Histopathology 51:204-218, 2007.
  • Lin YS*, Su LJ*, Yu R. CT*, Wong FH*, Yeh HH, Chen SL, Wu JC, Lin WJ, Shiue YL, Liu HS, Hsu SL , Lai JM, Huang F CY. Gene Expression Profiles of the Aurora Family Kinases. Gene expression 13:15-26, 2006.
  • Chang JL, Chen TH, Wang CF, Chiang YH, Huang YL, Wong FH, Chou CK, Chen CM. Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. Exp Cell Res. 312: 962-973, 2006.
  • Chang JT, Wong FH, Liao CT, Chen IH, Wang HM, Cheng AJ. Enzyme immunoassay for serum autoantibody to survivin and its findings in head-and-neck cancer patients. Clin Chem. 50(7):1261-1264, 2004.
  • Leu CM, Wong FH, Chang C, and Hu C. Interleukin-6 acts as an anti-apoptotic factor in human esophageal carcinoma cells through the activation of both STAT3 and mitogen-activated protein kinase pathways. Oncogene 22: 7809-7818, 2003.
  • Liu YC, Leu CM, Wong FH, Fong WS, Chen SC, Chang C, and Hu C. Autocrine stimulation by insulin-like growth factor I is involved in the growth, tumorigenicity, and chemoresistance of human esophageal carcinoma cells. J. Biochem. Sci. 9: 665-674, 2002.
  • Yu CC, Wong FH, Lo LJ, Chen YR. Hereditary cleft lip/palate and Wilms tumor: a rare association. Cleft Palate-Craniofacial Journal 39(3): 376-379, 2002.
  • Wong FH, Hu C, Chiu JH, Huang BS, Chien KY, Chang JP, Lin PJ, and Chang C. Expression of multiple oncogenes in human esophageal carcinomas. Cancer Investigation 12:121-131, 1994.
  • Chen SC, Chou CK, Wong FH, Chang C, and Hu C. Overexpression of epidermal growth factor and insulin-like growth factor-I receptors and autocrine stimulation in human esophageal carcinoma cells. Cancer Res. 51:1898-1903, 1991.

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