教師簡介

  • 專任助理教授
  • 陳嘉霖
  • Chia-Lin Chen
  • 02-2826-7000／lab: ext. 65734
  • clchen@nycu.edu.tw
  • 傳統醫學大樓甲棟1樓R121
  • 專業領域
  • 癌症代謝（Cancer Metabolism）、表觀遺傳學(Epigenetics)
  • 研究方向

  • 1.發掘代謝物（胺基酸、脂肪、碳水化合物）在癌症發展過程中所扮演的角色

    Metabolites were considered as intermediate products of metabolic pathways and served as different forms of energy resource. Emerging data has been shown that metabolites can act as growth factors, immuno-modulators, epigenetic regulators, etc., to govern various cellular functions. In this specific aim, we would like to uncover the novel roles of metabolites in tumorigenesis.

    • 2.探討粒腺體在癌症過程中所扮演的角色

    In the face of “Warburg effects” as dominant theory of cancer metabolism, the role of mitochondria in tumorigenesis was frequently neglected. However, aerobic glycolysis does not predict loss of mitochondrial functions. Increasing evidence has been shown mitochondrial activities need to be soundly maintained in cancer cells. In this specific aim, we would like to investigate the role of mitochondria in tumor progression and its implication for cancer therapy.

  • 重要研究成果

  • 1.在肝癌的腫瘤幹細胞(cancer stem cells)中，stemness gene, NANOG 會誘導癌細胞內的代謝反應重整 (metabolic reprogramming)。一方面，NANOG 會抑制粒腺體中的氧化磷酸化(oxidative phosphorylation) 反應來降低 ROS 的產生，以維持幹細胞的活性。另一方面，肝癌幹細胞會利用腫瘤微環境中的脂肪酸，並活化脂肪酸氧化(fatty acid oxidation) 代謝反應來作為產生能量的來源。




    • 2.在前列腺癌中，精胺酸(arginine) 在調節表觀遺傳修飾 (epigenetic modification)中扮演著重要的角色，特別是組織蛋白的乙醯化(histone acetylation)，進而調控電子傳遞鏈的蛋白質表現。值得一提的是，在癌細胞中，產生精胺酸的重要酵素ASS1的表現是被抑制的，導致癌細胞必須仰賴細胞外的精胺酸來源來維持粒腺體功能正常。因此，精胺酸剝奪療法(arginine deprivation therapy) 為癌症代謝療法帶來新的一線曙光。




  • 教授科目
  • 專題討論
    生涯發展與學習
  • 經歷
  • 08/2022–present
    國立陽明交通大學
    生命科學系暨基因體科學研究所
    助理教授
  • 10/2021–07/2022
    英屬哥倫比亞大學
    溫哥華前列腺癌症研究中心
    訪問學者
  • 09/2016–10/2021
    國家衛生研究院
    分子與基因醫學研究所
    博士後研究員
  • 學歷

  • 南加州大學
    遺傳分子細胞學
    博士


    國立中央大學
    生命科學系
    碩士


    東海大學
    畜產系
    學士


代表著作

    期刊發表

  • Sheng-Chieh Hsu*, Ching-Yu Lin*, Yen-Yi Lin, Colin C Collins,Chia-Lin Chen*, Hsing-Jien Kung#: TEAD4 as an oncogene and mitochondrial modulator. Frontiers Cell and Developmental Biology 2022 May 5, 10:890419. (#co-corresponding author)
  • Raphael Serna*, Ambika Ramrakhiani*, Juan Carlos Hernandez,Chia-Lin Chen*, Chad Nakagawa, Tatsuya Machida, Ratna Ray, Xiaohang Zhan, Stanley M. Tahara, Keigo Machida: c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity. iScience, 2022, April 26, 104325
  • Chia-Lin Chen*, Ching-Yu Lin, Hsing-Jien Kung: Targeting Mitochondrial OXPHOS and Their Regulatory Signals in Prostate Cancers. International Journal of Molecular Science. 2021 Dec 14; 22(24):13435.
  • Chia-Lin Chen*, Sheng-Chieh Hsu, David K Ann, Yun Yen, Hsing-Jien Kung: Arginine Signaling and Cancer Metabolism. Cancers (Basel). 2021 Jul 15;13(14):3541.
  • Sheng-Chieh Hsu,Chia-Lin Chen*, Mei-Ling Cheng, Cheng-Ying Chu, Chun A. Changou, Yen-Ling Yu, Shauh-Der Yeh, Tse-Chun Kuo, Cheng-Chin Kuo, Chih-Pin Chuu, Chien-Feng Li, Lu-Hai Wang, Hong-Wu Chen, Yun Yen, David K. Ann, Hung-Jung Wang, Hsing-Jien Kung: Arginine starvation elicits chromatin leakage and cGAS-STING activation via epigenetic silencing of metabolic and DNA-repair genes. Theranostics 2021; 11(15):7527-7545.
  • Chia-Lin Chen*, Sheng-Chieh Hsu*, Tan-Ya Chung, Cheng-Ying Chu, Hung-Jung Wang, Pei-Wen Hsiao, Shauh-Der Yeh, David K Ann, Yun Yen, Hsing-Jien Kung#: Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells. Nature Communications 04/2021; 12(1):2398. (*co-first author, #co-corresponding author). Featured article in the section of “From molecules and cells to organisms”
  • Hye Yeon Choi, Hifzur R Siddique, Mengmei Zheng, Yi Kou, Da-Wei Yeh, Tatsuya Machida, Chia-Lin Chen*, Dinesh Babu Uthaya Kumar, Vasu Punj, Peleg Winer, Alejandro Pita, Linda Sher, Stanley M Tahara, Ratna B Ray, Chengyu Liang, Lin Chen, Hidekazu Tsukamoto, Keigo Machida: p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs. Nature Communications 06/2020; 11(1):3084.
  • Nadiah Ghazalli, Xiaoxing Wu, Stephanie Walker, Nancy Trieu, Li-Yu Hsin, Justin Choe, Chia-Lin Chen*, Jasper Hsu, Jeanne LeBon, Mark T Kozlowski, Jeffrey Rawson, David A Tirrell, M. L. Richard Yip, Hsun Teresa Ku: Glucocorticoid Signaling Enhances Expression of Glucose-Sensing Molecules in Immature Pancreatic Beta-Like Cells Derived from Murine Embryonic Stem Cells In Vitro. Stem Cells and Development 05/2018; 27(13).
  • A Debebe, V Medina, C-Y Chen, I M Mahajan, C Jia, D Fu, L He, N Zeng, B W Stiles,Chia-Lin Chen*, M Wang, K-R Aggarwal, Z Peng, J Huang, J Chen, M Li, T Dong, S Atkins, Z Borok, W Yuan, K Machida, C Ju, M Kahn, D Johnson, B L Stiles: Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis. Oncogene 07/2017; 36(43).
  • Chia-Lin Chen*, Jeffrey Y. Huang, Chun-Hsiang Wang, Stanley M Tahara, Lin Zhou, Yasuteru Kondo, Joel Schechter, Lishan Su, Michael M C. Lai, Takaji Wakita, François-Loïc Cosset, Jae U Jung, Keigo Machida: Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2. Nature Communications 01/2017; 8:13882.
  • Dinesh Babu Uthaya Kumar*,Chia-Lin Chen*, Jian-Chang Liu, Douglas E. Feldman, Linda S. Sher, Samuel French, Joseph DiNorcia, Samuel W. French, Bita V. Naini, Sunhawit Junrungsee, Vatche Garen Agopian, Ali Zarrinpar, Keigo Machida: TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-initiating Stem-like Cells in Livers of Mice. Gastroenterology 03/2016; 150(707):719. (*co-first author)
  • Chia-Lin Chen*, Dinesh Babu Uthaya Kumar, Vasu Punj, Jun Xu, Linda Sher, Stanley M. Tahara, Sonja Hess, Keigo Machida: NANOG Metabolically Reprograms Tumor- Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism. Cell Metabolism 01/2016; 23(1).
  • Hifzur R. Siddique, Douglas E. Feldman,Chia-Lin Chen*, Vasu Punj, Hiroshi Tokumitsu, Keigo Machida: NUMB phosphorylation destabilizes p53 and promotes self- renewal of tumor-initiating cells by NANOG-dependent mechanism in liver cancer. Hepatology 08/2015; 62(5):1466-1479.
  • Raul Lazaro, Raymond Wu, Sunyoung Lee, Nian-Ling Zhu,Chia-Lin Chen*, Samuel W French, Jun Xu, Keigo Machida, Hidekazu Tsukamoto: Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice. Hepatology 01/2015; 61(1).
  • Chia-Lin Chen*, Hidekazu Tsukamoto, Keigo Machida: Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity. Hepatology International 06/2014; 8(3):330.
  • Chia-Lin Chen*, Hidekazu Tsukamoto, Jian-Chang Liu, Claudine Kashiwabara, Douglas Feldman, Linda Sher, Steven Dooley, Samuel W French, Lopa Mishra, Lydia Petrovic, Joseph H Jeong, Keigo Machida: Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells. The Journal of clinical investigation 06/2013; 123(7).
  • Douglas E Feldman,Chia-Lin Chen*, Vasu Punj, Keigo Machida: The TBC1D15 Oncoprotein Controls Stem Cell Self-Renewal through Destabilization of the Numb-p53 Complex. PLoS ONE 02/2013; 8(2):e57312.
  • Hui-Chen Ku, Hang-Seng Liu, Pei-Fang Hung,Chia-Lin Chen*, Hsien-Chun Liu, Hsin-Huei Chang, Yi-Wei Tsuei, Li-Jane Shih, Ching-Ling Lin, Chih-Ming Lin, Yung-Hsi Kao: Green tea (−)-Epigallocatechin gallate inhibits IGF-I and IGF-II stimulation of 3T3-L1 preadipocytemitogenesis via the 67-kDa laminin receptor, but not AMP-activated protein kinase pathway. Molecular Nutrition & Food Research 04/2012; 56(4):580-92.
  • Keigo Machida, Chia-Lin Chen,Chia-Lin Chen*, Claudine Kashiwabara, Douglas Feldman, Samuel W French, Linda Sher, Jeong Joseph Hyeongnam, Hidekazu Tsukamoto: Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus. Journal of Gastroenterology and Hepatology 03/2012; 27 Suppl 2(Suppl 2):19-22.
  • Douglas Edmund Feldman,Chia-Lin Chen*, Vasu Punj, Hidekazu Tsukamoto, Keigo Machida: Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells. Proceedings of the National Academy of Sciences 12/2011; 109(3):829-34.
  • Chia-Lin Chen*, Jing Chai, Lipi Singh, Ching-Ying Kuo, Liang Jin, Tao Feng, Scott Marzano, Sheetal Galeni, Nan Zhang, Michelina Iacovino, Lihui Qin, Manami Hara, Roland Stein, Jonathan S Bromberg, Michael Kyba, Hsun Teresa Ku: Characterization of an In Vitro Differentiation Assay for Pancreatic-Like Cell Development from Murine Embryonic Stem Cells: Detailed Gene Expression Analysis. Assay and Drug Development Technologies 03/2011; 9(4):403-19.
  • S-Y Lin,Chia-Lin Chen*, Y-L Wu, Y-C Yang, Y-M Hwu: Ratio of Wnt3a to BMP4 doses is critical to their synergistic effects on proliferation of differentiating mouse embryonic stem cells. Cell Proliferation 07/2008; 41(3):492-505.
  • Yung-Hsi Kao, Hsin-Huei Chang, Meng-Jung Lee,Chia-Lin Chen*: Tea, obesity, and diabetes. Molecular Nutrition & Food Research 02/2006; 50(2):188-210.
  • Pei-Fang Hung, Bo-Tsung Wu, Hui-Chian Chen, Yen-Hang Chen,Chia-Lin Chen*, Ming-Hua Wu, Hsien-Chun Liu, Meng-Jung Lee, Yung-Hsi Kao: Antimitogenic effect of green tea (-)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the ERK and Cdk2 pathways. AJP Cell Physiology 06/2005; 288(5):C1094-108.

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