教師簡介

  • 專任教授
  • 孫維欣
  • Wei-Hsin Sun
  • (02) 2826-7268 (office) / ext.66265 (Lab)
  • weihsin@nycu.edu.tw
  • 圖書資訊暨研究大樓7樓R708 (office) /R704 (Lab)

  • 專業領域
  • 慢性疼痛 、疼痛分子機制、神經免疫 、 G 蛋白偶合受體 、訊息傳遞 、止痛藥物開發
    Chronic pain, Molecular nociception, Neuroinflammation, G-protein coupled receptors, signal transduction, Drug discovery
  • 研究方向

  • 慢性疼痛若無有效紓解，將會嚴重影響個人生活品質及社會醫療成本。全球約有15億人口受慢性疼痛所苦，其中 3-4.5％為神經病變痛。 最大止痛藥市場仍為美國，但亞太市場近年來快速成長。新止痛藥發展的方向主要為關節炎、癌症及神經病變痛，然目前治療藥物侷限於副作用大或療效短 (30~40% 神經病變痛病人對單ㄧ治療有50%止痛療效)。因之，瞭解慢性疼痛的分子機制且找到止痛藥標的基因，有助於新止痛藥的發展。膜上G蛋白偶合受體接受多種胞外訊息，藉由訊息傳遞路徑調控胞內生理反應，與許多疾病皆有關聯性常為作為藥物的標的物。本實驗室主要以類風濕關節炎、周邊神經損傷所引發慢性疼痛為臨床疾病模式，利用基因剔除或沈默小鼠，佐以動物行為測試及細胞分子、生理與藥理、單細胞鈣離子影像分析，探討慢性疼痛的分子機制。目前的研究著重於幾個方向：

    • 急性疼痛轉換至慢性疼痛的分子機制：酸敏性G蛋白偶合受體於不同痛覺神經之交互作用機制
    • 腸道菌與腦的對話：迷走神經的神經免疫調控與腸道菌之影響
    • 周邊神經退化與慢性疼痛的分子機制：神經與神經膠細胞之交互作用機制
    • 性別對慢性疼痛之影響：神經內分泌與免疫細胞之交互作用機制
    • 止痛藥開發：利用細胞訊息與動物藥理測試進行藥物篩選，開發有效且具選擇性的止痛藥或治療方法，緩解持續性疼痛。

      Chronic pain, when not effectively treated and relieved, may have a harmful effect on all aspects of health-related quality of life. Although opioids and cannabinoids are well-known analgesic drugs of choice for the treatment of pain, their utility is often limited by unacceptable side effects due to actions at identical receptors outside of the pain pathway. Therefore, one of the major challenges in pain research is to identify potent drug targets with no side effects. G-protein-coupled receptors (GPCRs) that represent a major class of signal transduction play important roles in modulation of acute and chronic pain, which has highlighted their potential as pain targets. My long-term goal is to understand the molecular mechanisms of chronic pain using two major pain models, rheumatoid arthritis (Inflammatory/Nociplastic pain) and peripheral neuropathy (neuropathic pain). Current Research are focused on several areas: (1) The transition from the acute to chronic pain – modulation of proton-sensing GPCRs on distinct nociceptors; (2) Gut Microbe to Brain signaling and pain – neuroimmune modulation; (3) Peripheral nerve degeneration and pain – interaction between neurons and glial cells; (4) sexual diamorphism in functional pain syndromes – neurohormonal modulation; (5) Analgesic drug development. Genetic techniques (such as knockout, knockdown), pain behavioral tests, pharmacological assays, cell-based system, and calcium/sodium imaging techniques are used to study the mechanisms of chronic pain.
  • 教授科目
  • 生物化學、細胞訊息傳導與疾病

  • 經歷
  • 2020-2021
    Associate Dean and Division Head of International Admissions, Office of International Affairs, National Yang Ming Chiao Tung University, Taipei, Taiwan
    國立陽明交通大學國際事務處
    副國際長暨國際招生組組長
  • 2019-present
    Department of Life Sciences & Institute of Genome Sciences, National Yang-Ming University
    國立陽明交通大學
    生命科學系暨基因體科學研究所
    教授
  • 2016-2019
    Department of Life Sciences, National Central University
    國立中央大學生命科學系
    教授
  • 2011-2016
    Department of Life Sciences, National Central University
    國立中央大學生命科學系
    副教授
  • 2003-2011
    Department of Life Sciences, National Central University
    國立中央大學生命科學系
    助理教授
  • 1999-2003
    National Institute of Mental Health, National Institutes of Health, U.S.A.
    美國國家衛生院
    博士後研究員
  • 學歷
  • 1999
    King’s College London
    (英國倫敦大學國王學院)
    分子生物學 博士
  • 1992
    National Taiwan University
    (國立臺灣大學)
    農業化學系 學士

代表著作

    Peer-reviewed papers

  • Nguyen NT, *Sun WH., Chen TH, Tsai PC, Chen CC, Huang SL (2022) Gut Mucosal Microbiome Is Perturbed in Rheumatoid Arthritis Mice and Partly Restored after TDAG8 Deficiency or Suppression by Salicylanilide Derivative. International Journal of Molecular Science 23, 3527 (first two are equal contribution) (MOST 106-2320-B-008-004-MY3; 109-2320-B-010-027-MY3)
  • Kung CC, Huang YC, Hung TY, Teng CY, Lee TY, *Sun WH. (2020) Deletion of Acid-sensing ion channel 3 relieves the late phase of neuropathic pain by preventing neuron degeneration and promoting neuron repair. Cells 9, 2355 (MOST 105-2320-B-008-003, MOST 106-2320-B-008-004-MY3)
  • Wu TY, Kung CC, Kao TY, *Sun WH. (2020) Innovative Mind–Body Intervention Day Easy Exercise Increases Peripheral Blood CD34+ Cells in Adults. Cell Transplantation 29:1-9 (MOST 105-2320-B-008-003, MOST 106-2320-B-008-004-MY3)
  • Dai SP, Hsieh WS, Chen CH, Lu YH, Huang HS, Chang DM, Huang SL, *Sun WH. (2020) TDAG8 deficiency reduces satellite glial number and pro-inflammatory macrophage number to relieve rheumatoid arthritis disease severity and chronic pain. J Neuroinflammation, 17:170 (MOST 106-2320-B-008-004-MY3)
  • Kung CC, Dai SP, Chiang H, Huang HS, *Sun WH. (2020) Temporal expression patterns of distinct cytokines and M1/M2 macrophage polarization regulate rheumatoid arthritis progression. Molecular Biology Reports, 47, 3423-3437. (MOST 106-2320-B-008-004-MY3; VGHUST106-G1-3-3)
  • Chung YC, Lee CH, Sun WH, Chen CC. (2018) Involvement of advillin in somatosensory neuron subtypes-specific axon regeneration and neuropathic pain. PNAS 115:E8557-8566.
  • Madda R, Lin SC, *Sun WH, *Huang SL. (2018) Differential expressions of plasma proteins in systemic lupus erythematosus patients identified by proteomic analysis. J Microbiol Immunol Infect. pii:S1684-1182 (103CGH-NCU-A4)
  • Madda R, Lin SC, *Sun WH, *Huang SL. (2018) Plasma proteomic analysis of systemic lupus erythematosus patients using liquid chromatography/tandem mass spectrometry with label-free quantification. Peer J 6: e4730 (MOST 106-2320-B-008-004-MY3)
  • Sun WH (2018) Tackling pain associated with rheumatoid arthritis: proton-sensing receptors in Abstracts of the 7th Asian Pain Symposium. Mol Pain 14, 24
  • Su YS, Mei HR, Wang CH, *Sun WH (2018) Peripheral 5-HT3 mediates mirror-image pain by a cross-talk with acid-sensing ion channel 3. Neuropharmacology 130: 92-104 (MOST 104-2320-B-008-001, MOST 106-2320-B-008-004-MY3)
  • S, Huang YF, Wong J, Lee CW, Hsieh WS, *Sun WH (2018) G2A as a threshold regulator of inflammatory hyperalgesia modulates chronic hyperalgesia. J Mol Neurosci. 64: 39-50 (MOST105-2320-B-008-003)
  • Hsieh WS, Kung CC, Huang SL, Lin SC and *Sun WH(2017) TDAG8, TRPV1, and ASIC3 involved in establishing hyperalgesic priming in experimental rheumatoid arthritis. Scientific Reports 7:8870 (MOST104-2745-B-008-001; 103CGH-NCU-A4)
  • Dai SP, Huang YH, Chang CJ, Huang YF, Hsieh WS, Tabata Y, Ishii S, and *Sun WH (2017) TDAG8 involved in initiating inflammatory hyperalgesia and establishing hyperalgesic priming in mice. Scientific Reports 7:41415 (MOST103-2321-B-008-001; MOST104-2321-B-008-001)
  • Lin SH, Steinhoff M, Ikoma A, Chang YC, Cheng YR, Chandra Kopparaju R, Ishii S, *Sun WH, *Chen CC. (2017) Involvement of TRPV1 and TDAG8 in pruriception associated with noxious acidosis. J Invest Dermatol 137:170-178 (MOST 104-2320-B-008-001)
  • Su YS,*Sun, WH(2016) Commentary: Serotonin Receptor 2B Mediates Mechanical Hyperalgesia by Regulating Transient Receptor Potential Vanilloid 1. J Neurol Neuromed (2016) 1(6): 23-26.
  • Su YS, Chang CJ, and *Sun, WH(2016) Heteromerization of OGR1 and G2A enhances proton sensitivity and proton-induced calcium signals. J Recept Signal Transduct Res 36:633-644. (NSC102-2321-B-008-001; MOST 103-2321-B-008-001)
  • Lee CC, Chen CL, Liu FL, Chiou CY, Chen TC, Wu CC, Sun WH, Chang DM, and Huang HS. (2016) Development of 1-Amino-4-(phenylamino)anthraquinone-2-sulfonate Sodium Derivatives as a New Class of Inhibitors of RANKL-Induced Osteoclastogenesis Development of 1-Amino-4-(phenylamino)anthraquinone-2-sulfonate Sodium Derivatives as a New Class of Inhibitors of RANKL-Induced Osteoclastogenesis. Arch. Pharm. Chem. Life Sci. 349(5):342-55.
  • Su YS, Chiu YY, Lin SY, Chen CC and *Sun WH(2016) Serotonin receptor 2B mediates mechanical hyperalgesia by regulating transient receptor potential vanilloid 1 in isolectin B4-negative neurons. J Mol Neurosci. 59:113-125 (NSC992320-B-008-001-MY3, NSC102-2321-B-008-001)
  • Sun WH and Chen CC. (2016) Roles of Proton-Sensing Receptors in the Transition from Acute to Chronic Pain. J Dent Res 95: 135-142 (MOST103-2321-B-008-001)
  • Huang WY, Dai SP, Chang YC,*Sun WH (2015) Acidosis Mediates the Switching of Gs-PKA and Gi-PKCε Dependence in Prolonged Hyperalgesia Induced by Inflammation. PLoS One 10(5): e0125022 (NSC101-2321-B-008-001 and NSC102-2321-B-008-001)
  • Lin SH, Sun WH, Chen CC (2014) Genetic exploration of the role of acid-sensing ion channels. Neuropharmocology 94:99-118
  • Chen WN, Lee CH, Lin SH, Wong CW,Sun WH, Wood JN, Chen CC. (2014) Roles of ASIC3, TRPV1, and Nav1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia. Mol Pain. 10(1):40.
  • Su YS, Sun WH, Chen CC (2014) Molecular mechanism of inflammatory pain. World Journal of Anesthesiology 3:71-81 (NSC 101-2321-B-008-001 equal contribution to the first two authors)
  • Huang YH, Chang CY, Chen CC, Yang CD and *Sun WH (2013) Distinct expression of Mas1-related G-protein-coupled receptor B4 in dorsal root and trigeminal ganglia-implications for altered behaviors in acid-sensing ion channel 3-deficient mice. J Mol Neurosci 51, 820-834 (NSC 101-2321-B-008-001, NCU-LSH-101-A-002 SCI)
  • Wu WL, Cheng CF, Sun WH, Wong CW, Chen CC (2012) Targeting ASIC3 for pain, anxiety, and insulin resistance. Pharmacol & Therapeut 134, 127-138
  • Lin SY, Chang WJ, Lin CS, Huang CY, Wang HF and*Sun WH(2011) Serotonin receptor 5-HT2B mediates serotonin-induced mechanical hyperalgesia. J Neuorsci. 31, 1410-1418 (NSC 95-2311-B-008-004 and NSC 99-2320-B-008-001-MY3)
  • Chen, YJ, Huang, CW, Lin, CS, Chang, WH and *Sun, WH (2009) Expression and function of proton-sensing G protein-coupled receptors in inflammatory pain. Molecular Pain 5, 39 (NSC 96-2311-B-008-005-MY2) (highly accessed article)
  • Huang, CW, Tzeng, JN, Chen, YJ, Tsai, WF, Chen, CC, and *Sun WH(2007) Nociceptors of dorsal root ganglion express proton-sensing G protein-coupled receptors. Mol Cell Neurosci 36, 195-210 (NSC93-2311-B-008-007)
  • Fang YC, *Sun WH, Wu LC, Huang HD, Juan HF, and *Horng JT. (2006) RINGdb: An integrated database for G-protein-coupled receptors and regulators of G protein signaling. BMC genomics 7: 317 (NSC 92-2321-B-008-001)
  • Chen CC, Zimmer A, Sun WH, Hall J, Brownstein MJ, Zimmer A. (2002). A role for ASIC3 in the modulation of high-intensity pain stimuli. PNAS 99, 8892-8897
  • Sun WH, and Coleman T, and DePamphilis M. (2002). Cell cycle-dependent regulation of the association between origin recognition proteins and somatic cell chromatin. EMBO J 21,1437-1446
  • Sun WH, Hola, M., Baldwin, N., Pedley, K., and Brooks, R.F. (2001). Heterogeneity in nuclear transport does not affect the timing of DNA synthesis in quiescent mammalian nuclei induced to replicate in Xenopus egg extracts. Cell prolif. 34, 55-67
  • Natale D, Li CJ, Sun WH, and DePamphilis M. (2000). Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M to G1 transition in mammals. EMBO J 19, 2728-2738
  • Sun WH, Hola M, Pedley K, Tada S, Blow JJ, Todorov IT, Kearsey SE, and Brooks RF. (2000). The replication capacity of intact mammalian nuclei in Xenopus egg extracts declines with quiescence, but the residual DNA synthesis is independent of Xenopus MCM proteins. Journal of Cell Science 113, 683-695
  • Longothetou-Rella H, Sun WH, and Brooks RF. (2000). Induction of DNA synthesis or apoptosis in mammalian nuclei by Xenopus egg extracts unable to support the replication of sperm chromatin. Cell Biology International 24, 129-134

    Book Chapters

  • Sun WH, Su YS. (2021) Roles of 5-HT2B receptor in pain. In 5-HT2B Receptors: From Molecular Biology to Clinical Applications. Ed by Luc Maroteaux and Laurent Monassier, Springer, p143-152 (ISBN: 978-3-030-55919-9; ISBN: 978-3-030-55920-5 (eBook))
  • Sun WH, Su YS, Chen CC (2019) The transition from acute to chronic pain. In the Neurobiology of pain. Ed by Wood J. Oxford University press (ISBN: 9780190860509)
  • *Sun WH and Dai SP (2018) Tackling pain associated with rheumatoid arthritis. In Advances in Pain Research: Mechanisms and Modulation of Chronic Pain. Adv Exp Med Biol. 1099:49-64. Ed. by Shyu BC and Tominaga M. Springer, Singapore （ISBN: 978-981-13-1755-2）
  • Sun, WH and Chen, CC. (2010) ASIC3 and proton-sensing G protein-coupled receptors. In Nociceptive and Neuropathic pain: mechanisms and treatments. Ed. by Shyu B.C. and Chien CC. Research Signpost p33-52. (ISBN: 978-81-308-0368-5) (NSC93-2311-B-008-007)
  • Sun, W.H., and DePamphilis, M. (2004) Methods for detecting cells in S phase. In Methods Mol Biol 241, 37-53. Edited by Lieberman, H.B. Humana Press Inc., Totowa, NJ.

    Patents

  • 孫維欣、黃雪莉、黃旭山. 蒽醌[2,1-c][1,2,5]噻二唑-6,11-二酮化合物緩解疼痛的應用. Taiwan patent No: I533869, 2016/5/21-2034/3/10 (NSC 102-2321-B-008-001)
  • 孫維欣、黃雪莉、黃旭山. 萘并[2,3-f] 喹喔啉-7,12-二酮化合物緩解疼痛的應用. Taiwan patent No: I 533871, 2016/5/21-2034/3/10 (NSC 102-2321-B-008-001)
  • Sun WH, Huang SL, Huang HS. Indication of naphtho[2,3-f]quinoxaline-7,12-dione compound in alleviating pain. USA patent No: US9284281, 2016/3/15~2034/10/23 (NSC 102-2321-B-008-001)
  • Sun WH, Huang SL, Huang HS. Indication of anthra[2,1-c][1,2,5] thiadiazole-6,11-dione compound in alleviating pain. USA patent No: US9192602 B2, 2015/11/24~2034/9/16 (NSC 102-2321-B-008-001)
  • Huang SL, Lin SC, Sun WH. Use of tumor necrosis factor (tnf) receptor-associated factor 7 (traf7) as biomarker for systemic lupus erythematosus (sle), method and kit for detecting of human with SLE. Japan patent No:6193806, 2017/8/18-2033/8/18 (103CGH-NCU-A4; 104CGH-NCU-A4)
  • 黃雪莉，林世昌，孫維欣 腫瘤壞死因子受體相關因子7作為紅斑性狼瘡的生物標記物之用途、偵測人體患有紅斑性狼瘡的方法以及偵測人體患有紅斑性狼瘡的套組Taiwan patent No: I 502199, 2015/10/1- 2033/5/22 (103CGH-NCU-A4; 104CGH-NCU-A4)

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