其他師資
專任師資
兼任師資
合聘師資
退休師資
教師簡介
- 專任助理教授
- 陳虹如
- Hong-Ru Chen
- 02-2826-7000／lab: ext. 67099
- hrchen@nycu.edu.tw
- 生物醫學大樓7樓R709
- 實驗室網頁
- https://sites.google.com/view/hrchen709/chen-lab
- 專業領域
- Neuroimmunology, Neonatal Brain Injury, Stroke, Autism, and Tauopathy
- 研究方向
-
Our primary research interest is to investigate how neurons and monocyte-derived pathological microglia interact to mediate neural physiology and behavior in various neurological conditions, towards the development of immune-targeted therapies of the disease condition. The diseases that we study include maternal immune activation, neonatal hypoxia-ischemia (HI), infection-sensitized HI, and neonatal stroke. To test this idea, we have developed a two-hit model of neurodevelopmental defects by subjecting the offspring of murine maternal immune activation (MIA) under a moderate Rice-Vannucci HI insult to produce autistic-like behaviors and synaptic defects.
Our second research interest is to explore the disease model of neuropil clumps caused by phosphorylated tau protein, and how monocytes are involved in the regulation of myelin damage and to develop the new therapeutic methods in neurodegenerative diseases (such as Alzheimer's disease and tauopathy).
- 教授科目
- 專題討論
生涯發展與學習
- 經歷
- 08/2022–present
國立陽明交通大學
生命科學系暨基因體科學研究所
助理教授 - 02/2021–07/2022
University of Virginia School of Medicine
Department of Neuroscience
Assistant Professor - 01/2018–01/2021
University of Virginia School of Medicine
Department of Neuroscience
Research Associate - 12/2015–12/2017
Emory University School of Medicine
Department of Pediatrics
Postdoctoral Research Fellow - 08/2015–11/2015
National Yang-Ming University
Brain Research Center
Postdoctoral Research Fellow - 學歷
● Ph.D.Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan
● Trainee. Embryology Course, Marine Biological Laboratory, MA, USA
● M.S.Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
● B.S.Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
代表著作
- Yu-Yo Sun, Hui-Wen Yao., Ching-Wen Chen, Melissa M Kinkaid, Chia-Yi Kuan (2022, Sep) Stroke Propensity in a Mouse Model of b-Thalassemia Intermedia. Neurobiology of Disease, 171, 105802
- ,Ton DeGrauw, Chia-Yi Kuan (2022, Mar) (Phospho)creatine: The Reserve and Merry-Go-Round of Brain Energetics. Neural Regeneration Research, 18 (2)327-328,
- ,Ching-Wen Chen, Yi-Min Kuo, Brandon Chen, Irena S. Kuan, Henry Huang, Jolly Lee, Neil Anthony, Chia-Yi Kuan, Yu-Yo Sun (2022, Jan). Monocytes promote acute neuroinflammation and become pathological microglia in neonatal hypoxic-ischemic brain injury. Theranostics,https://www.thno.org/v12p0512.htm
- Kanchan Bisht1, Kenneth A. Okojie, Kaushik Sharma, Dennis H. Lentferink, Yu-Yo Sun,, Joseph O. Uweru, Saipranusha Amancherla, Zainab, Calcuttawala, Antony Brayan Campos Salazar, Bruce Corliss, Lara Jabbour, Jordan Benderoth, Bria Friestad, William A. Mills III, Brant Isakson, Marie-Ève Tremblay, Chia-Yi Kuan and Ukpong B. Eyo (2021, Aug). Capillary-associated microglia regulate vascular structure and function. Nature communications, https://doi.org/10.1038/s41467-021-25590-8.
- , Xiaohui Zhang-Brotzge, Yury M Morozov, Yuancheng Li, Siming Wang, Helen Zhang, Irena S Kuan, Elizabeth M Fugate, Hui Mao, Yu-Yo Sun, Pasko Rakic, Diana M Lindquist, Ton DeGrauw, Chia-Yi Kuan (2021, July). Creatine transporter deficiency impairs stress-adaptation and brain energetics homeostasis. JCI Insight,https://doi.org/10.1172/jci.insight.140173.
- , Ching-Wen Chen, Nandita Mandhani, Jonah C Short-Miller, Marchelle R Smucker, Yu-Yo Sun, Chia-Yi Kuan (2020, Dec). Monocytic Infiltrates Contribute to Autistic-like Behaviors in a Two-Hit Model of Neurodevelopmental Defects. Journal of Neuroscience, 40 (49) 9386-9400
- Chia-Yi Kuan,, Ning Gao, Yi-Min Kuo, Ching-Wen Chen, Dianer Yang, Melissa M Kinkaid, Erding Hu, Yu-Yo Sun (2020, Nov). Brain targeted hypoxia- inducible factor stabilization reduces neonatal hypoxic ischemic brain injury. Neurobiology of Disease, 148:105200
- , Yu-Yo Sun, Ching-Wen Chen, Yi-Min Kuo, Irena S Kuan, Zheng-Rong Tiger Li, Jonah C Short-Miller, Marchelle R Smucker, Chia-Yi Kuan (2020, Aug). Fate mapping via CCR2-CreER mice reveals monocyte-to microglia transition in development and neonatal stroke. Science Advances, DOI:10.1126/sciadv.abb2119
- Yu-Yo Sun*, Yi-Min Kuo*,, Jonah C Short-Miller, Marchelle R Smucker, Chia-Yi Kuan (2020, Apr). A murine photothrombotic stroke model with an increased fibrin content and improved responses to tPA-lytic treatment. Blood Advances, 4(7): 1222– 1231
- , Hsien-Chia Juan, Yu-Hui Wong, Jin-Wu Tsai, Ming-Ji Fann (2017, Mar). Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex. Cerebral Cortex, 27(3): 2289–2302
- Hsien-Chia Juan, Yong Lin,, Ming-Ji Fann (2016, Jun). Cdk12 is essential for embryonic development and the maintenance of genomic stability. Cell Death and Differentiation, 23, 1038–1048
- , Guan-Ting Lin, Chun-Kai Huang, Ming-Ji Fann (2014, Nov). Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression. Experimental Neurology, 261: 10-21
- , Hung-Chi Yang, Dennis Jine-Yuan Hsieh, Zijuan Liu, Kan-Jen Tsai (2011, Feb). Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status. Chemico-Biological Interactions, 189 (3) 192- 197
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