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1.發掘代謝物(胺基酸、脂肪、碳水化合物)在癌症發展過程中所扮演的角色
Metabolites were considered as intermediate products of metabolic pathways and served as different forms of energy resource. Emerging data has been shown that metabolites can act as growth factors, immuno-modulators, epigenetic regulators, etc., to govern various cellular functions. In this specific aim, we would like to uncover the novel roles of metabolites in tumorigenesis.2.探討粒腺體在癌症過程中所扮演的角色
In the face of “Warburg effects” as dominant theory of cancer metabolism, the role of mitochondria in tumorigenesis was frequently neglected. However, aerobic glycolysis does not predict loss of mitochondrial functions. Increasing evidence has been shown mitochondrial activities need to be soundly maintained in cancer cells. In this specific aim, we would like to investigate the role of mitochondria in tumor progression and its implication for cancer therapy.1.在肝癌的腫瘤幹細胞(cancer stem cells)中,stemness gene, NANOG 會誘導癌細胞內的代謝反應重整 (metabolic reprogramming)。一方面,NANOG 會抑制粒腺體中的氧化磷酸化(oxidative phosphorylation) 反應來降低 ROS 的產生,以維持幹細胞的活性。另一方面,肝癌幹細胞會利用腫瘤微環境中的脂肪酸,並活化脂肪酸氧化(fatty acid oxidation) 代謝反應來作為產生能量的來源。
2.在前列腺癌中,精胺酸(arginine) 在調節表觀遺傳修飾 (epigenetic modification)中扮演著重要的角色,特別是組織蛋白的乙醯化(histone acetylation),進而調控電子傳遞鏈的蛋白質表現。值得一提的是,在癌細胞中,產生精胺酸的重要酵素ASS1的表現是被抑制的,導致癌細胞必須仰賴細胞外的精胺酸來源來維持粒腺體功能正常。因此,精胺酸剝奪療法(arginine deprivation therapy) 為癌症代謝療法帶來新的一線曙光。
南加州大學
遺傳分子細胞學
博士
國立中央大學
生命科學系
碩士
東海大學
畜產系
學士
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