教師簡介

  • 專任教授
  • 林照雄
  • Chao-Hsiung Lin
  • 02-2826-7280/lab: ext. 65777 or 65786
  • chaohsiunglin@nycu.edu.tw
  • 傳統醫學大樓甲棟1樓R112
  • 專業領域
  • Metabolomics, Proteomics, Post-translational modifications, Mass spectrometry & Chemical biology
  • 研究方向
  • 癌細胞相關蛋白的功能研究: Primary interest of my lab is to study protein functions through diverse omics techniques as well as chemical biology. Current focus is the hnRNPK protein that participates in many cell events, including chromatin recruiting, transcription regulation, RNA splicing and translation regulation. Moreover, amplification of hnRNPK is associated with cancer progression, migration and prognosis. Recently, we demonstrated that two essential arginine methylation of hnRNPK is able to suppress the apoptotic induction of DNA damage in cancer cells. The mechanism regarding how these arginine methylations assist cancer cells to survive from apoptosis is under study.

    以人類血液代謝體研究發展老化指標分子: Using a metabolomics approach, we have collaborated with physicians at Taipei Veteran’s General Hospital to develop serum biomarkers. The current focus is to identify the potential metabolites of which serum alterations are associated with healthy aging or risk of cardiovascular diseases.

    抗癌天然物穿心蓮內酯的分子藥理機制: Andrographolide is a major component of Andrographis paniculata leaves employed for medicinal use, including the anti-inflammatory and neuroprotective activities. Through collaboration with Prof. Shu-Ling Fu (Institute of Traditional Medicine, NYMU), we have demonstrated that andrographolide can inhibit SARS-CoV2 main protease, reduce monoacyl lipase level and suppress migration of cancer cells. The mechanism regarding how andrographolide exhibits biological activity through diverse targets as well as the development of more effective andrographolide derivatives are under study.

  • 教授科目
  • 有機化學
    有機化學實驗
    化學生物學─蛋白體與代謝體研究方法
    代謝體學
    生命科學技術
  • 經歷
  • Feb. 2022-present
    國立陽明交通大學
    生命科學院
    副院長
  • Feb. 2014-present
    國立陽明交通大學
    生命科學系暨基因體科學研究所
    教授
  • Aug. 2015-present
    國立陽明大學
    生命科學系暨基因體科學研究所
    所長
  • Aug. 2007-Jan. 2014
    國立陽明大學
    生命科學系暨基因體科學研究所
    副教授
  • Aug. 1998-Jul. 2007
    國立陽明大學生命科學系
    助理教授
  • Nov. 1995-Jul. 1998
    美國加州Scripps研究所化學系
    博士後研究
  • Aug. 1989-Jul. 1990
    國立臺灣大學化學系
    研究助理
  • 學歷
  • Sep. 1990-Oct. 1995
    美國紐約州立大學石溪分校化學系
    博士
  • Sep. 1983-Jun. 1987
    國立臺灣大學化學系
    學士

代表著作(過去五年)

  • Chin-Chou Huang*, Yi-Long Huang, Chao-Hsiung Lin*, Jaw-Wen Chen (2021, Nov). Plasma Metabolomic Profiles Associated with Hypertension and Blood Pressure in Response to Thiazide Diuretics. Hypertension Research, 45(3), 464.
  • Yi-Long Huang, Zhao-Qing Shen, Chen-Hua Huang, Chao-Hsiung Lin, Ting-Fen Tsai* (2021, Nov). Cisd2 slows down liver aging and attenuates age-related metabolic dysfunction in male mice. Aging Cell, 20(12), e13523.
  • Lin-Chieh Chiu, Jir-You Wang, Chao-Hsiung Lin, Chung-Hua Hsu , Lie-Chwen Lin*, Shu-Ling Fu* (2021, Oct). Diterpenoid compounds Isolated from Chloranthus oldhamii Solms Exert Anti-Inflammatory Effects by Inhibiting the IKK/NF-kB Pathway. Molecules, 26(21), 6540.
  • Yi-Long Huang, Chao-Hsiung Lin, Tsung-Hsien Tsai, Chen-Hua Huang, Jie-Ling Li, Liang-Kung Chen, Chun-Hsien Li, Ting-Fen Tsai*, Pei-Ning Wang* (2021, Oct). Discovery of a Metabolic Signature Predisposing High Risk Patients with Mild Cognitive Impairment to Converting to Alzheimer's Disease. International Journal of Molecular Sciences, 22(20),10903.
  • Chen-Hua Huang, Yi-Long Huang, Zhao-Qing Shen, Chao-Hsiung Lin*, Ting-Fen Tsai* (2021, Sep). Cisd2 Preserves the Youthful Pattern of the Liver Proteome during Natural Aging of Mice. Biomedicines, 9(9), 1229.
  • Chiao-Che Chen, Jen-Hao Yang, Shu-Ling Fu, Wey-Jinq Lin, Chao-Hsiung Lin* (2021, Sep). Arginine Methylation of hnRNPK Inhibits the DDX3-hnRNPK Interaction to Play an Anti-Apoptosis Role in Osteosarcoma Cells. International Journal of Molecular Sciences, 22(18), 9764.
  • Yi-Long Huang, Zhao-Qing Shen, Chen-Hua Huang, Yuan-Chi Teng, Chao-Hsiung Lin*, Ting-Fen Tsai* (2021, Apr). Cisd2 Protects the Liver from Oxidative Stress and Ameliorates Western Diet-Induced Nonalcoholic Fatty Liver Disease. Antioxidants (Basel), 10(4), 559.
  • Pei-Chang Lee, Yun-Chen Hsieh, Teh-Ia Huo, Ueng-Cheng Yang, Chao-Hsiung Lin, Chung-Pin Li, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin, Kuei- Chuan Lee* (2021, Feb). Active Vitamin D 3 Treatment Attenuated Bacterial Translocation via Improving Intestinal Barriers in Cirrhotic Rats. Molecular Nutrition & Food Research, e2000937.
  • Tzu-Hau Shi, Yi-Long Huang, Chiao-Che Chen, Wen-Chieh Pi, Yu-Ling Hsu, Lee-Chiang Lo, Wei-Yi Chen, Shu-Ling Fu*, Chao-Hsiung Lin* (2020, Dec). Andrographolide and itsfluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 533(3), 467–473.
  • Yi-Ju Chou, Ching-Cheng Lin, Ivan Dzhagalov, Nien-Jung Chen, Chao-Hsiung Lin, Chun-Cheng Lin, Szu-Ting Chen, Kuo-Hsin Chen* and Shu-Ling Fu* (2020, May). Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy.. Sci Rep., 10(1), 8422.
  • Mei Yin Liu, Wei Kai Hua, Yi‐Ying Chiou, Chi‐Ju Chen, Chao‐Ling Yao, Yi‐Ting Lai, Chao‐Hsiung Lin, Wey‐Jinq Lin* (2020, Jan). Calcium‐dependent methylation by PRMT1 promotes erythroid differentiation through the p38α MAPK pathway. FEBS Letters, 594(2), 301-316.
  • Hsin‐Chia Liao, Yi‐Ju Chou, Ching‐Cheng Lin, Sheng‐Hung Liu, Audrey Oswita, Yi‐Long Huang, Ying‐Lien Wang, Jia‐Ling Syu, Chung‐Ming Sun, Chuen‐Miin Leu, Chao‐Hsiung Lin, Shu‐Ling Fu* (2019, May). Andrographolide and its potent derivative exhibit anticancer effects against imatinib‐resistant chronic myeloid leukemia cells by downregulating the Bcr‐Abl oncoprotein. Biochemical Pharmacology, 163(2), 308-20.
  • Hsin Yu Tsai, Shu Ling Fu, Ling Ming Tseng, Jen‐Hwey Chiu, Chao‐Hsiung Lin* (2019, May). hnRNPK S379 phosphorylation participates in migration regulation of triple negative MDA‐MB‐231 cells. Scientific Reports, 9(1):7611.
  • Yun‐Chen Tsai, Sin‐Ling Wang, Mei‐Yao Wu, Chia‐Huei Liao, Chao‐Hsiung Lin, Jih‐Jung Chen*, Shu‐Ling Fu* (2018, Dec). Pilloin, A Flavonoid Isolated from Aquilaria sinensis, Exhibits Anti‐Inflammatory Activity In Vitro and In Vivo. Molecules, 23(12), pii:E3177.
  • Hsu-Feng Chu, Chiao-Che Chen, David C. Moses, Yau-Hung Chen, Chao-Hsiung Lin, Ying-Chieh Tsai, Chi-Yuan Chou* (2018, Oct). Porcine epidemic diarrhea virus papain-like protease 2 can be noncompetitively inhibited by 6-thioguanine. Antiviral Research, 158, 199-205.
  • Ching-Wen Chang, Yu-Syuan Chen, Yeou-Guang Tsay, Chia-Li Han, Yu-Ju Chen, Cheng-Chieh Yang, Kai-Feng Hung, Chao-Hsiung Lin, Tsung-Yen Huang, Shou-Yen Kao, Te-Chang Lee and Jeng-Fan Lo* (2018, Feb). ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells. Cell Death & Disease, 9(2), 194.
  • Yi‐Long Huang, Zhao‐Qing Shen, Chia‐Yu Wu, Yuan‐Chi Teng, Chen‐Chung Liao, Cheng‐Heng Kao, Liang‐Kung Chen, Chao‐Hsiung Lin*, Ting‐Fen Tsai* (2018, Feb). Comparative proteomic profiling reveals a role for Cisd2 in skeletal muscle aging. Aging Cell, 17(1), e12705.
  • Wei-Ting Liu, Wu-Chun Tu, Chao-Hsiung Lin, Ueng-Cheng Yang, Cheng-Chen Chen* (2017, Nov). Involvement of cecropin B in the formation of the Aedes aegypti mosquito cuticle. Scientific Reports, 7(1),16395.
  • Yi-Long Huang, Zhao-Qing Shen, Chia-Yu Wu, Yuan-Chi Teng, Chen-Chung Liao, Cheng-Heng Kao, Liang-Kung Chen, Chao-Hsiung Lin*, Ting-Fen Tsai* 2017, Nov. "Comparative proteomic profiling reveals a role for Cisd2 in skeletal muscle aging" Aging Cell, in press.
  • Wei-Hung Tan, Shu-Chun Cheng, Yu-Tung Liu, Cheng-Guo Wu, Min-Han Lin, Chiao-Che Chen, Chao-Hsiung Lin, Chi-Yuan Chou* 2016, Aug. " Structure of a Highly Active Cephalopod S-crystallin Mutant: New Molecular Evidence for Evolution from an Active Enzyme into Lens-Refractive Protein" Scientific Reports, 31176.
  • Ya-Hsin Hsu , Yu-Ling Hsu , Sheng-Hung Liu, Hsin-Chia Liao, Po-Xuan Lee, Chao-Hsiung Lin, Lee-Chiang Lo, Shu-Ling Fu* 2016, Apr. "Development of a Bifunctional Andrographolide-Based Chemical Probe for Pharmacological Study" PLoS ONE, e0152770.
  • Yao-Ping Lin, Wen-Chung Yu, Meng-Erh Hsu, Hsiao-Chien Tsai, Chen-Chung Liao*, Chao-Hsiung Lin 2015, Apr. "Comparative proteomic analysis of rat left ventricle in a subtotal nephrectomy model" J Chin Med Assoc, 218-228.
  • Yi-Ling Wang, Gan-Guang Liou, Chao-Hsiung Lin, Mong-Liang Chen, Tzer-Min Kuo, Kuen-Nan Tsai, Chien-Choao Huang, Ya-Ling Chen, Li-Rung Huang, Yu-Chi Chou, Chungming Chang* 2015, Mar. " The inhibitory effect of the hepatitis B virus singly-spliced RNA-encoded p21.5 protein on HBV nucleocapsid formation" PLoS ONE, e0119625.
  • Jen-Hao Yang, Yi-Ying Chiou, Shu-Ling Fu, I-Yun Shih, Tsai-Hsuan Weng, Wey-Jinq Lin, and Chao-Hsiung Lin* 2014, Nov. "Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation" Nucleic Acids Res, 9908-9924.
  • Min-Han Lin, Shang-Ju Chuang, Chiao-Che Chen, Shu-Chun Cheng, Kai-Wen Cheng, Chao-Hsiung Lin, Chiao-Yin Sun*, and Chi-Yuan Chou* 2014, Jun. "Structural and functional characterization of MERS coronavirus papain-like protease" Journal of Biomedical Science, 54.
  • Yan-Su Lin, Yi-Long Huang, Wen-Fu Lee*, and Chao-Hsiung Lin* 2014, May "Property and Application of BACy-Based Functional Hydrogels" Journal of the Chinese Chemical Society, 945-952.
  • Chih-Hao Wang, Yi-Fan Chen, Chia-Yu Wu, Pei-Chun Wu, Yi-Long Huang, Cheng-Heng Kao, Chao-Hsiung Lin, Lung-Sen Kao, Ting-Fen Tsai*, and Yau-Huei Wei* 2014, May "Cisd2 modulates the differentiation and functioning of adipocytes by regulating intracellular Ca2+ homeostasis" Human Molecular Genetics, 4770-4785.
  • Sheng-Hung Liu, Chao-Hsiung Lin, Fong-Ping Liang, Pei-Fen Chen, Cheng-Deng Kuo, Mohd. Mujahid Alam, Barnali Maiti, Shih-Kai Hung, Chin-Wen Chi, Chung-Ming Sun* and Shu-Ling Fu* 2014, Jan. "Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy" Biochemical Pharmacology, 229-242.
  • Yan-Su Lin, Chao-Hsiung Lin, and Wen-Fu Lee* 2014, Jan. "Investigation of the synthesis and properties of the copolymeric hydrogels based on N-isopropyl acrylamide and acrylamidoazo- benzene" Journal of Polymer Research, 364.
  • Fong-Lee Huang, Young-Ji Shiao, Sheue-Jane Hou, Cheng-Ning Yang, Yi-Jen Chen, Chao-Hsiung Lin, Feng-Shiun Shie and Huey-Jen Tsay* 2013, Aug. "Cysteine-rich domain of scavenger receptor AI modulates the efficacy of surface targeting and mediates oligomeric Aβ internalization" Journal of Biomedical Science, 54.
  • Yong-Shiang Lin, Chao-Hsiung Lin, Li-De Huang, Tung Chao, Cheng-Deng Kuo, Ling-Chien Hung, Fen-Hwa Wong, Chun-Cheng Lin* and Shu-Ling Fu* 2013, Jul. "The suppression of thoc1 in cancer cell apoptosis mediated by activated macrophages is nitric oxide-dependent" Biochemical Pharmacology, 242-252.
  • Sheng-Hui Tsai, Gwan-Han Shen, Chao-Hsiung Lin, Jiue-Ru Liau, Hsin-Chih Lai, and Shiau-Ting Hu* 2013, Jun. "Mab_3168c, a Putative Acetyltransferase, Enhances Adherence, Intracellular Survival and Antimicrobial Resistance of Mycobacterium abscessus" PLoS ONE, e67563.
  • Kai-Wei Hsueh, Shu-Ling Fu, Chirn-Bin Chang, Yu-Ling Chang and Chao-Hsiung Lin* 2013, Feb. "A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2" BBA-Proteins and Proteomics, 508-515.
  • Yan-Su Lin, Hsuan-Hsuan Lee, Wen-Fu Lee and Chao-Hsiung Lin* 2013, Feb. "Synthesis and qualitative analysis of BACy and its self-polymer" Journal of the Chinese Chemical Society, 223-228.
  • Chih-Liang Tien, Chao-Hsiung Lin, Ting-Hui Lin, Feng-Chen Wen, Chien-Wei Su, Sheng-Seen Fan and Mingli Hsieh* 2012, Sep. " Secreted cyclophilin A induction during embryo implantation in a model of human trophoblast-endometrial epithelium interaction" European Journal of Obstetrics & Gynecology and Reproductive Biology, 55-59.
  • Yi-Long Huang, Tsai-Wen Chung, Chia-Mao Chang, Chih-Hau Chen, Chen-Chung Liao, Yeou-Guang Tsay, Gwo-Chyuan Shaw, Shwu-Huey Liaw, Chung-Ming Sun* and Chao-Hsiung Lin* 2012, Aug. "Qualitative analysis of the fluorophosphonate-based chemical probes targeting recombinant and endogenous serine hydrolase" Analytical and Bioanalytical Chemistry, 2387-2396.
  • Yao-Ping Lin, Chih-Yu Yang, Chen-Chung Liao, Wen-Chung Yu, Chin-Wen Chi and Chao-Hsiung Lin* 2012, Jul. "Plasma protein characteristics of long-term hemodialysis survivors". PLoS One, 7, e40232.
  • Yi-Chang Liu, I-Hsuan Lin, Wei-Jen Chung, Wensi S. Hu, Wailap Victor Ng,Chi-Yu Lu, Tsung-Yen Huang, Hung-Wei Shu, Kwang-Jen Hsiao, Shih-Feng Tsai, Chuan-Hsiung Chang* and Chao-Hsiung Lin* 2012, Apr. "Proteomics characterization of cytoplasmic and lipid-associated membrane proteins of human pathogen Mycoplasma fermentans M64" PLoS One, e35304.
  • Yi-Feng Huang, Jing-Jer Lin, Chao-Hsiung Lin, Yeu Su* and Shih-Chieh Hung* 2012, May "c-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP-2 via phosphorylation of Runx2 at Ser104" Journal of Bone and Mineral Research, 1093-1105.
  • Yi-Ying Chiou, Shu-Ling Fu, Wey-Jinq Lin, and Chao-Hsiung Lin* 2012, Feb. "Proteomics analysis of in vitro protein methylation during Src-induced transformation" Electrophoresis 451-461.